Theory
Substitution means replacing a letter with the number you have been given.
In algebra, 3x means 3 multiplied by x. If x = 5, then 3x becomes 3 * 5.
If the value is negative, put it in brackets before calculating. This is especially important with powers.
If a letter appears more than once, replace every occurrence of that letter.
After substituting, use the normal order of operations: brackets, powers, multiplication/division, then addition/subtraction.
Edexcel often gives formulae in context. Write the substituted line first so method marks are clear even if an arithmetic slip happens later.